The .22-250 Remington cartridge is known for its high velocity and flat trajectory, making it a popular choice for varmint hunting and long-range target shooting. While lighter projectiles are favored for maximizing velocity and minimizing wind drift, heavier bullets offer increased sectional density and energy retention, potentially leading to improved terminal performance on larger varmints or at extended ranges. Generally, commercially available projectiles for this caliber range from 35 to 90 grains. The heaviest commonly available bullets typically weigh around 90 grains, though some specialty manufacturers might offer slightly heavier options.
Selecting the appropriate projectile weight depends on the intended application. Heavier bullets, while typically traveling at lower velocities, can deliver greater impact energy downrange and penetrate deeper. This can be advantageous when hunting larger varmints like coyotes or when aiming for longer shots. The increased mass helps maintain momentum and resist deflection by wind or intervening obstacles. Historically, lighter bullets have been preferred for smaller varmints like prairie dogs due to their explosive terminal effects and flatter trajectories at shorter ranges.